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KMID : 0617219950060010027
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Duksung Bulletin Phamaceutical Sciences
1995 Volume.6 No. 1 p.27 ~ p.34
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Effects of Bupleurum falcatum Extract on the Acute Acetaminophen-Induced Hepatotoxicity
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Abstract
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The present study was designed to examine the antihepatotoxic effect of Bupleurum falcatum extract. The ratio of liver weight to body weight changes in serum enzyme activities, serum cholesterol, bilirubin and urea nitrogen contents were measured in the rats treated with Bupleurum falcatum extract(1g/㎏, p.o.) followed by the administration of acetaminophen(AAP, 1800㎎/㎏, p.o.). The ratio of liver weight to body weight in the rats treated with AAP was 30% greater than that in untreated rats. Treatment of animals with both Bupleurum falcatum extract and AAP caused decreases in the ratio as compared with treatment of animals treated with AAP alone : 65% by methanol ex., 33% by hexan fr., 93% by ether fr., 21% by ethyl acetate fr., 56% by butanol fr. and 38% by aqueous fr. Fifty eight to sixty nine % decreases in GOT and GPT activities were observed in the animals treated with both AAP and Bupleurum falcatum extract as compared with those from AAP treated rats. Treatment of rats with Bupleurum falcatum extract caused decreases in AAP induced elevation of serum ALP activities, total cholesterol, total bilirubin and urea nitrogen contents by 37%, 48%, 59%, and 39% respectively. Treatment of animals with both AAP and aqueous. fr. of Bupleurum falcatum extract resulted in dcreases in serum enzyme activities of GOT, GPT, ALP, serum cholesterol, bilirubin and urea nitrogen contents by 77%, 92%, 62%, 85%, 82%, 48%, relative to the animals treated with AAP alone. These results show that Bupleurum falcatum extract contains the components which are active against AAP-induced liver damage.
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